Publications

1.        Zecchin A*, Wong BW*, Tembuyser B, Souffreau J, Van Nuffelen A, Wyns S, Vinckier S, Carmeliet P, Dewerchin M. Live imaging reveals a conserved role of fatty acid ß-oxidation in early lymphatic development in zebrafish. Biochem Biophys Res Commun. 2018 (in press). 

2.        Wong BW, Zecchin A, Garcia-Caballero M, Carmeliet P. Developmental aspects of lymphangiogenesis: Emerging focus on novel regulators and organ-specific function. Dev Cell. 2018; 45: 289-301. Review. 

3.       Eelen G, de Zeeuw P, Treps L, Harjes U, Wong BW, Carmeliet P. Endothelial cell metabolism. Physiol Rev. 2018; 98: 3-58. Review. 

4.       Wong BW, Marsch E, Treps L, Baes M, Carmeliet P. Endothelial cell metabolism in health and disease: Impact of hypoxia. EMBO J. 2017; 36: 2187-2203. Review. 

5.       Wong BW*, Wang X*, Zecchin A*, Thienpont B, Cornelissen I, Kalucka J, García-Caballero M, Missiaen R, Huang H, Brüning U, Blacher S, Vinckier S, Goveia J, Knobloch M, Zhao H, Dierkes C, Shi C, Hägerling R, Moral-Dardé V, Wyns S, Lippens M, Jessberger S, Fendt SM, Luttun A, Noel A, Kiefer F, Ghesquière B, Moons L, Schoonjans L, Dewerchin M, Eelen G, Lambrechts D, Carmeliet P. Role of fatty acid ß-oxidation in lymphangiogenesis. Nature. 2017; 542:49-54. 

6.       Chatur S, Wong BW, Carthy JM, McManus BM. Inhibition of vascular endothelial growth factor reduces cardiac allograft vasculopathy. J Heart Lung Transplant. 2016; 35: 1124-1130. 

7.       Cruys B, Wong BW, Kuchnio A, Verdegem D, Vinckier S, Merks RM, Dewerchin M, Gerhardt H, Bentley K, Carmeliet P. Glycolytic regulation of cell rearrangement in angiogenesis. Nat Commun. 2016; 7: 12240. 

8.       de Zeeuw P, Wong BW, Carmeliet P. Metabolic adaptations in diabetic endothelial cells. Circ J. 2015; 79: 934-941. Review. 

9.       Ghesquière B, Wong BW, Kuchnio A, Carmeliet P. Metabolism of stromal and immune cells in health and diseases. Nature. 2014; 511: 167-176. Review. 

10.    Schoors S*, De Bock K*, Cantelmo AR, Georgiadou M, Ghesquière B, Cauwenberghs S, Kuchnio A, Wong BW, Quaegebeur A, Goveia J, Blanco R, Tembuyser B, Cornelissen I, Bouché A, Vinckier S, Diaz-Moralli S, Gerhardt H, Telang S, Cascante M, Chesney J, Dewerchin M, Carmeliet P. Partial and transient reduction of glycolysis by PFKFB3 blockade reduces pathological angiogenesis. Cell Metab. 2014; 19: 37-48. 

11.    Schoors S, Cantelmo AR, Georgiadou M, Stapor P, Wang X, Wong BW, Bifari F, Quaegebeur A, Decimo I, Schoonjans L, De Bock K, Dewerchin M, Carmeliet P. Incomplete and transitory decrease of glycolysis: A new paradigm for anti-angiogenic therapy? Cell Cycle. 2014; 13: 16-22. 

12.    De Bock K*, Georgiadou M*, Schoors S, Kuchnio A, Wong BW, Cantelmo AR, Quaegebeur A, Ghesquière B, Cauwenberghs S, Eelen G, Phng LK, Betz I, Tembuyser B, Brepoels K, Welti J, Geudens I, Segura I, Cruys B, Bifari F, Decimo I, Blanco R, Wyns S, Vangindertael J, Rocha S, Collins RT, Munck S, Daelemans D, Imamura H, Devlieger R, Rider M, Van Veldhoven PP, Schuit F, Bartrons R, Hofkens J, Fraisl P, Telang S, Deberardinis RJ, Schoonjans L, Vinckier S, Chesney J, Gerhardt H, Dewerchin M, Carmeliet P. Role of PFKFB3-driven glycolysis in vessel sprouting. Cell. 2013; 154: 651-663. 

13.    Wong BW, Kuchnio A, Bruning U, Carmeliet P. Emerging novel functions of the oxygen-sensing prolyl hydroxylase domain enzymes. Trends Biochem Sci. 2013; 38: 3-11. Review. 

14.    Wong BW, Meredith A, Lin D, McManus BM. The biological role of inflammation in atherosclerosis. Can J Cardiol. 2012; 28: 631-641. Review. 

15.    Carmeliet P, Wong BW, De Bock K. Treating diabetes by blocking a vascular growth factor. Cell Metab. 2012; 16: 553-555. Preview. 

16.    Wong BW, Wong D, Luo H, McManus BM. Vascular endothelial growth factor-D is overexpressed in human cardiac allograft vasculopathy and diabetic atherosclerosis and induces endothelial permeability to low-density lipoproteins in vitro. J Heart Lung Transplant. 2011; 30: 955-962. 

17.    Garmaroudi FS, Marchant D, Si X, Khalili A, Bashashati A, Wong BW, Tabet A, Ng RT, Murphy K, Luo H, Janes KA, McManus BM. Pairwise network mechanisms in the host signaling response to coxsackievirus B3 infection. Proc Natl Acad Sci USA. 2010; 107: 17053-17058. 

18.    Allahverdian S, Wang A, Singhera GK, Wong BW, Dorscheid DR. Sialyl Lewis X modification of the epidermal growth factor receptor regulates receptor function during airway epithelial wound repair. Clin Exp Allergy. 2010; 40: 607-618. 

19.    Luo H, Wong J, Wong B. Protein degradation systems in viral myocarditis leading to dilated cardiomyopathy. Cardiovasc Res. 2010; 85: 347-356. Review. 

20.    Wong BW, Rahmani M, Luo Z, Yanagawa B, Wong D, Luo H, McManus BM. Vascular endothelial growth factor increases human cardiac microvascular endothelial cell permeability to low-density lipoproteins. J Heart Lung Transplant. 2009; 28: 950-957. 

21.    Choi HY, Rahmani M, Wong BW, Allahverdian S, McManus BM, Pickering JG, Chan T, Francis GA. ATP-binding cassette transporter A1 expression and apolipoprotein A-I binding are impaired in intima-type arterial smooth muscle cells. Circulation. 2009; 119: 3223-3231. 

22.    MacDonald ML, van Eck M, Hildebrand RB, Wong BW, Bissada N, Ruddle P, Kontush A, Hussein H, Pouladi MA, Chapman MJ, Fievet C, van Berkel TJ, Staels B, McManus BM, Hayden MR. Despite antiatherogenic metabolic characteristics, SCD1-deficient mice have increased inflammation and atherosclerosis. Arterioscler Thromb Vasc Biol. 2009; 29: 341-347. 

23.    Hunter AL, Zhang J, Chen SC, Si X, Wong B, Ekhterae D, Luo H, Granville DJ. Apoptosis repressor with caspase recruitment domain (ARC) inhibits myogenic differentiation. FEBS Lett. 2007; 581: 879-884. 

24.    Yuan J, Lim T, Liu Z, Qiu D, Wong B, Luo H, Si X, McManus B, Yang D. Antisense DNA and RNA: Potential therapeutics for viral infection.  Anti-Infect Agents Med Chem. 2006; 5: 367-377. Review. 

25.    Rahmani M, Wong BW, Ang L, Cheung CC, Carthy JM, Walinski H, McManus BM. Versican: signaling to transcriptional control pathways. Can J Physiol Pharmacol. 2006; 84: 77-92. Review. 

26.    Wong BW, Rahmani M, Rezai N, McManus BM. Progress in heart transplantation. Cardiovasc Pathol. 2005; 14: 176-180. Review. 

27.    Zhang HM, Yuan J, Cheung P, Chau D, Wong BW, McManus BM, Yang D. Gamma interferon-inducible protein 10 induces HeLa cell apoptosis through a p53-dependent pathway initiated by suppression of human papillomavirus type 18 E6 and E7 expression. Mol Cell Biol. 2005; 25: 6247-6258. 

28.    Yuan J, Zhang J, Wong BW, Si X, Wong J, Yang D, Luo H. Inhibition of glycogen synthase kinase 3beta suppresses coxsackievirus-induced cytopathic effect and apoptosis via stabilization of beta-catenin. Cell Death Differ. 2005; 12: 1097-1106. 

29.    Rahmani M, Read JT, Carthy JM, McDonald PC, Wong BW, Esfandiarei M, Si X, Luo Z, Luo H, Rennie PS, McManus BM. Regulation of the versican promoter by the beta-catenin-T-cell factor complex in vascular smooth muscle cells. J Biol Chem. 2005; 280: 13019-13028. 

30.    Rahmani M, McDonald PC, Wong BW, McManus BM. Transplant vascular disease: role of lipids and proteoglycans. Can J Cardiol. 2004; 20 Suppl B: 58B-65B. Review. 

31.    Choy JC, Kerjner A, Wong BW, McManus BM, Granville DJ. Perforin mediates endothelial cell death and resultant transplant vascular disease in cardiac allografts. Am J Pathol. 2004; 165: 127-133. 

32.    Zhang HM, Yuan J, Cheung P, Luo H, Yanagawa B, Chau D, Stephan-Tozy N, Wong BW, Zhang J, Wilson JE, McManus BM, Yang D. Overexpression of interferon-gamma-inducible GTPase inhibits coxsackievirus B3-induced apoptosis through the activation of the phosphatidylinositol 3-kinase/Akt pathway and inhibition of viral replication. J Biol Chem. 2003; 278: 33011-33019. 

33.    Wong BW, Wong D, McManus BM. Characterization of fractalkine (CX3CL1) and CX3CR1 in human coronary arteries with native atherosclerosis, diabetes mellitus, and transplant vascular disease. Cardiovasc Pathol. 2002; 11: 332-338.